Stanford-LPCH
Vaccine Program–

Clinical Trials

 Completed Studies

Current Studies

The following are ongoing vaccine clinical trials conducted by the Stanford-LPCH Vaccine Program. For more information about clinical trials and a nationwide database of clinical trials, please go to ClinicalTrials.gov.

For general information about participant rights, contact 1-866-680-2906

Our clinic location is at 800 Welch Road, Palo Alto, CA 94304. General phone # (650) 498-7284. Please click below to view a map to our clinic.

Instructions and Driving Directions to Center for Translationsal Research (FCTR)

Map to the Freidenrich Center for Translational Research (FCTR)

 

When you click "JOIN OUR MAILING LIST " icon, please join our mailing list so we can contact you.

Mailing List

Links to studies:

Seasonal Flu Vaccine Studies

We have several seasonal flu vaccine studies each year in the fall.
Find your age below to be directed to the appropriate trials:



Enrolling Now

18 and older
2012-2013 Immune Responses to Influenza-Like Illness




18-70 years old (Enrollment closed)
2012-2013 Experimental Seasonal Influenza DNA Vaccine Study

18-30 years old
Seasonal Flu Vaccine Study: For 18-30 years old (Enrollment closed)
Adult Seasonal Flu Vaccine Study - Longitudinal Study (Closed to new enrollments)
Twin Seasonal Flu Vaccine Study (T-cell  Responses) (Enrollment closed)

18-32 years old (Enrollment closed)
Seasonal Flu Vaccine Study (Referrals from past SLVP studies only)

18-49 years old (Enrollment closed)
Seasonal Flu Vaccine Study 2012-2013

40-64 years old (Enrollment closed)
Twin Seasonal Flu Vaccine Study (T-cell  Responses)

60-100 years old
Adult Seasonal Flu Vaccine Study - Longitudinal Study (Closed to new enrollments)
Adult Seasonal Flu Vaccine Study (CMV Study) (Referrals from Stanford Blood Center only) (Enrollment closed)

65-100 years old (Enrollment closed)
Twin Seasonal Flu Vaccine Study (T-cell  Responses)
Shingles Vaccine Study (Age-Related Immune Responses to Varicella Zoster Virus) (Enrollment closed)


Enrollment Closed
Spring 2012 Flu Vaccine Study (Enrollment closed)
NIH-Sponsored Malaria Vaccine Trial (Enrollment Closed)






Enrolling Now

ILIImmune Responses to Influenza-like Illness

Summary:  Stanford LPCH Vaccine program is seeking adults, age 18 years or older, who are currently experiencing flu-like symptoms to participate in a flu research study. The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Mark M. Davis, Ph.D., Professor of Microbiology and Immunology and Dr. Harry B. Greenberg, M.D., Senior Associate Dean for Research.  The goal is to investigate how the adult immune system responds to natural infection by this season’s influenza viruses.

Study Participation, to qualify you must have:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu





DNA_Vaccine 2012-2013 Experimental Seasonal Influenza DNA Vaccine Study (Enrollment closed)
                 
An Open-Label, Randomized Phase 1b Study of the Safety and Immunogenicity of Investigational Seasonal Influenza DNA Vaccine (HA DNA), Followed by Trivalent Inactivated VAccine (TIV) Administered Intradermally (ID) or Intramuscularly (IM) in Healthy Adults Ages 18-70 Years (VRC703)

SUMMARY The Stanford-LPCH Vaccine Program is seeking healthy adults to take part in an experimental universal flu vaccine study.  The purpose of this trial is to study the the safety and effectiveness of three different  seasonal flu vaccines.  The other main purpose is to see which vaccination schedules result in the best immune responses.  The research will be conducted at Stanford University by Cornelia L. Dekker, M.D., Professor of Pediatrics.  This trial is sponsored by the National Institutes of Health (NIH). Three different types of flu vaccines are being studied. Two are regular seasonal flu vaccine that is approved by the Food and Drug Administration (FDA) for use in the influenza season. The other vaccine is experimental and is not approved by the FDA.  

You will be randomly assigned to one of 6 groups.

Groups 1 and 2: [Enrollment for Groups 1 & 2 is closed] Volunteerswill be assigned to receive a DNA vaccine in September 2012 and then be given a booster with a licensed seasonal flu vaccine in November/December 2012.
Groups 3-6: Volunteers will be assigned to receive any combination of DNA vaccine and/or a licensed seasonal flu vaccine in November/December 2012 and then be given a booster of a licensed seasonal flu vaccine in approximately August/September 2013.

To qualify you should be:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **  To review a copy of the informed consent, please click this link: ** Informed Consent**

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu or Join Our Mailing List (see Link on left-side of web page).
For general information about participant rights, contact 1-866-680-2906





Flu
Seasonal Flu Vaccine Study: For 18-30 years old (Enrollment closed)

(Fall 2012 HIPC IOF: The Human Mucosal Immune Responses to Influenza Virus: A Systems Biology Approach: CCHI DF: Innate Immune Responses to Influenza Virus in Single Human Nasal Epithelial Cells)

SUMMARY The Stanford-LPCH Vaccine Program is seeking healthy 18-30 years old to take part in an influenza (commonly known as "the flu") vaccine study. In this study we will compare the immune cell responses to flu vaccine in nasal mucosal cells and in blood. We hope the information learned from this study will help identify and describe important factors in the early-stage development of influenza immunity and possibly lead to the development of more effective vaccines. All flu vaccines used in this study are licensed by the FDA and are not experimental. These are the same seasonal flu vaccines that will be used for the public during the flu season.
The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection), and Harry Greenberg, MD.
To be eligible, you must be

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **
For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu




Flu CMV
Adult Seasonal Flu Vaccine Study (CMV Study): (Enrollment closed)
The Influence of Chronic Cytomegalovirus Infection on Influenza Vaccine Responses
(Referrals from Stanford Blood Center only)


SUMMARY The Stanford-LPCH Vaccine Program (SLVP) is seeking healthy adults 60 years of age or older to take part in an influenza (commonly known as "the flu") vaccine study. In this study we are trying to understand whether previous infection with a particular virus, namely cytomegalovirus, influences the ability of the immune system to respond to new infections or vaccinations with age. Cytomegalovirus is a very common virus; more than 50% of all individuals older than 60 years have had an infection without knowing it. The flu vaccine used in this study is licensed by the FDA and is not experimental. This is the same seasonal flu vaccine that will be used for the public during the fall flu season.
The research will be conducted at Stanford University School of Medicine by Dr. Jorg Goronzy, M.D., Ph.D., Professor of Medicine, (Institute of Immunity Transplantation and Infection), Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program) and Dr. Edgar Engleman, M.D., Director, Stanford Blood Center.
To be eligible you should be referred by the Stanford Blood Center and be:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu





Flu
Seasonal Flu Vaccine Study 2012-2013 (Enrollment closed)
U19 Influenza Immunity: Protective Mechanisms Against a Pandemic Respiratory Virus. Project 1: B-cell Immunity to Influenza. (SLVP024)




SUMMARY: The Stanford-LPCH Vaccine Program is seeking healthy 2-8 year old children or 18-49 year old adults to take part in an influenza (commonly known as "the flu") vaccine study. In this study we will be looking at the differences in the immune response between different age groups. The vaccine used in both age groups is licensed by the FDA and is not experimental. This is the same seasonal flu vaccine that will be used for the public during the fall flu season.
We will compare the B-cell responses by analyzing vaccine-immune responses in the blood and nasal mucosal cells.

The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program) , Dr. Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection) and and Dr. Harry B. Greenberg, M.D., Senior Associate Dean for Research.

To be eligible, you or your child must fall in one of the two age groups and meet the following criteria:

Group A: 2-8 years old:

Group B: 18-49 years old:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu






T-CellSeasonal Flu Vaccine Study (T-cell  Responses 2012-2013) (Enrollment closed)
T-cell and General Immune Responses to Influenza, Single-cell Phospho-protein Signaling Analysis of the Response to Influenza Vaccination and Measuring the Immunome: Genomic Approaches to B-cell Repertoire


SUMMARY: The Stanford-LPCH Vaccine Program is seeking healthy twin volunteers to take part in an influenza (commonly known as "the flu") vaccine study.  This study will investigate markers and mechanisms and define general predictors for immunological health. This goal is analogous to what has been achieved in cardiovascular medicine where the levels of different forms of cholesterol have provided useful benchmarks for cardiovascular health.

In this context, immunization with approved flu vaccines represents a safe and accessible opportunity to gauge the immune response in a particular individual as a function of age and genetics and then to try to find predictive biomarkers. The vaccines used are licensed by the FDA and are not experimental.  They are the same seasonal flu vaccines that will be used for the public during the fall flu season.  The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program) and Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection)
 

To qualify you should be:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 oremail us at Vaccines_Program@stanford.edu

If you are a twin, and would like to join the Twin Research Registry at SRI International (not affiliated with Stanford University), call 1-800-SRI-TWIN (1-800-774-8946).  You may be eligible to participate in other research studies that could help scientists advance new treatments for diseases and explain the roles of genetics and the environment in health and behavior.





SHIMR

Seasonal Flu Vaccine Study: For 18-32 years old (Enrollment closed)
Vaccination and infection: indicators of immunological health and responsiveness; Project 1: Plasmablast trafficking and antibody response in influenza vaccination - 2012 (Referrals from past studies only)


SUMMARY: The Stanford-LPCH Vaccine Program is seeking healthy 18-32 year olds to take part in an influenza (commonly known as "the flu") vaccine study. In this study, we will be looking at the differences in the immune response between two types of licensed seasonal flu vaccines. You will be assigned to receive a single dose of the flu vaccine either into the muscle of the arm (standard flu shot) or into the skin of the arm (the intradermal flu shot). All vaccines are licensed by the FDA and are not experimental. These are the same seasonal flu vaccines that will be used for the public during the fall flu season.

We will compare the B-cell immune responses by analyzing the trafficking receptor expression on vaccine-induced plasmablasts, their immunoglobulin gene-repertoire, as well as functions of PPAb derived from plasmablast subsets based on trafficking receptor phenotypes.

The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program) and Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection)

To be eligible, you must have received a flu shot in the 2010 or 2011 flu season (either into the arm muscle or skin of the upper arm) and should be:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu






Adult Seasonal Flu Vaccine Study - Longitudinal Study
(Closed to new enrollments)

Flu

Immune Senescence in the Elderly: Comparison of Immune Reponses to Influenza Vaccine in Adults of Different Age Groups




SUMMARY: The Stanford-LPCH Vaccine Program is seeking healthy adults to take part in an influenza vaccine study (commonly known as "the flu").  We hope to discover new biological markers that are associated with the age-related immune response to the seasonal flu vaccine. 
The flu vaccine used in this study is licensed by the FDA and is not experimental.  Because we are interested in understanding how the immune response changes over time in the same individual, volunteers will be asked to participate for as many years as possible through 2014.

The research will be conducted at Stanford University by Cornelia L. Dekker, M.D., Professor of Pediatrics, and by Mark M. Davis, Ph.D., Professor of Microbiology and Immunology.  The trial is sponsored by the National Institutes of Health, and the Bill and Melinda Gates Foundation.

To be eligible you should be:
Generally Healthy                                                                                              
18-30 or 60-100 years old at time of enrollment
Able to attend 4 clinic visits at Stanford
Able to provide 4 blood samples

If eligible, you will receive:
Current licensed seasonal flu vaccine
$30 per clinic visit attended
Parking vouchers

ELIGIBILITY:
The study is open to volunteers who have been previously enrolled in this study and to new volunteers. To view the eligibility requirements and visit schedule, please click this link: ** Eligibility Criteria and Visit Schedule  **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu





Flu
Stanford Flu Vaccine Study: For 18-30 years old (Enrollment Closed)
Spring 2012 Pilot Study in Young Adults to Examine the Kinetics of Changes in the B-cell Repertoire Following TIV Immunization


SUMMARY: The Stanford-LPCH Vaccine Program is seeking healthy 18-30 years old to take part in an influenza (commonly known as "the flu") vaccine study. The purpose is to investigate B-cell response to the influenza vaccine in healthy young adults.  In particular, we will use unique strategies to study in detail the immune responses of immunoglobulins and antibody CDR3 before and after immunization.  The flu vaccine used in this study is licensed by the FDA and is the same seasonal flu vaccine that is used for the public during the 2011-2012 flu season.

The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection) and Dr. Stephen Quake, Professor of Bioengineering, Co-Chair, Department of Bioengineering.
 
To be eligible, you should:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu




Varicella
Varicella Zoster Virus (VZV)
Study of Age-Related Immune Responses to VZV (Enrollment closed)
T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape

Summary:  The Stanford-LPCH Vaccine Program is seeking healthy adults to take part in a study of the immune system of individuals who have had chickenpox in the past in order to learn more about  the influence of age and inherited factors on VZV-specific T cell response in naturally-acquired VZV immunity and the response to VZV vaccination. This knowledge may lead to an improvement in vaccination strategies and identification of ways to improve vaccine responses in older individuals. 


Study Participation
The varicella zoster virus (VZV) causes chickenpox (also known as varicella) the first time a person is infected.  However, decades after a person has had chickenpox, the virus can reactivate in the body to cause a condition called shingles (also known as zoster).  We will measure the immune responses to the naturally-acquired varicella zoster virus in order to learn more about age-related differences in immune function.  We will also study the vaccine-induced responses in volunteers 50 years of age and older.  The trial is sponsored by National Institutes of Health.  There are two parts to the study:  one for volunteers between the ages of 40-49 years and another for volunteers 50 years of age and older.

Participation for volunteers 40-49 years of age will include one clinic visit with one blood draw. (Volunteers in this age group will not receive the shingles vaccine)

Participation for volunteers 50 years of age and older will include five clinic visits with five blood draws.  This age group will also receive a free shingles vaccination.  The vaccine is licensed by the FDA and is not experimental.  The vaccine is recommended for individuals 50 years of age and older and has been shown to help prevent shingles and to reduce the severity and duration of those who develop shingles. 

The research will be conducted at Stanford University School of Medicine by Jorg Goronzy, M.D., Ph.D., Professor of Medicine and Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics (Stanford-LPCH Vaccine Program).   

Volunteers will receive reimbursement for each clinic visit completed.  There will be no costs for participating in the study and parking vouchers will be provided. 

Eligibility:

Stanford Medicine Resources:

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