Stanford-LPCH
Vaccine Program

Clinical Trials

Completed Studies

Current Studies

The following are ongoing vaccine clinical trials conducted by the Stanford-LPCH Vaccine Program. For more information about clinical trials and a nationwide database of clinical trials, please go to ClinicalTrials.gov.

For general information about participant rights, contact 1-866-680-2906

Our clinic location is at 800 Welch Road, Palo Alto, CA 94304. General phone # (650) 498-7284.


 

When you click "JOIN OUR MAILING LIST " icon, please join our mailing list so we can contact you.

Mailing List

Links to studies:

Seasonal Flu Vaccine Studies

We have several seasonal flu vaccine studies each year in the fall.
Find your age below to be directed to the appropriate trials:



Enrolling Now



NON-TWIN STUDIES
Children

6 mo-4 years old (SLVP029)
6 mo-8 years old (SLVP030)
8-34 years old (SLVP021)
9-13 years old (SLVP029)

Adults
18-30 years old (SLVP015)
18-49 years old (SLVP029)

TWIN STUDIES
Children
2-5 years old (SLVP030)

Children and Adults
12-49 years old (SLVP028)
18 years and older (SLVP031)


Adult 60-100 years old
Adult Seasonal Flu Vaccine Study - Longitudinal Study (Closed to new enrollments)

1-3 years old and 18 and older (Enrollment Closed)
Immune Responses to Influenza-like Illness





Flu_SLVP029 Innate and Acquired Immunity to Influenza Infection and Immunization
(B-cell Study; SLVP029)

The purpose of this NIH-sponsored clinical trial is to provide a better understanding of the natural and adaptive immune response to the flu virus and to compare the immune cell responses to flu vaccine in nasal mucosal cells and in blood. We hope the information learned from this study will help identify and describe important factors of influenza immunity especially B-cell responses at different stages of life especially during infancy and possibly lead to the development of more effective vaccines.

Volunteers will receive one of two FDA-licensed influenza vaccines, either the inactivated vaccine given as a flu shot, or the live, attenuated vaccine given as a nasal spray. These are the same seasonal flu vaccines that are used for the public during the flu season.

The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection), and Harry Greenberg, MD. Senior Associate Dean of Research.
We are enrolling children and adults for this study.  To be eligible you or your child must be:

For your participation, you will receive $30.00 compensation for each completed visit and parking vouchers for clinic visits.
ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu





Flu_SLVP030The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection
(T-cell Study; SLVP030)
 
The purpose of this NIH-sponsored clinical trial is to provide a better understanding of the immune response to the licensed flu vaccine. We hope the information learned from this study will help identify and describe important factors of influenza immunity, especially T-cell responses in the early stages of life. This knowledge may lead to the development of more effective vaccines.  

Your child will receive one of two FDA-licensed influenza vaccines, either the inactivated vaccine given as a flu shot, or the live, attenuated vaccine given as a nasal spray. These are the same seasonal flu vaccines that are used for the public during the flu season.

The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection)
We are enrolling children for this study.  To be eligible your child must be:

You will receive compensation and parking vouchers for your participation.
ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:

Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu





SHIMR
Seasonal Flu Vaccine Study: For 8-34 years old
Vaccination and infection: indicators of immunological health and responsiveness; Project 1: Plasmablast trafficking and antibody response in influenza vaccination. SLVP021 - 2014


The Stanford-LPCH Vaccine Program is seeking healthy children and young adults age 8-34 year olds to take part in an influenza (commonly known as "the flu") vaccine study. Participants must have either participated in this study previously (2012 and/or 2013) or a new participant who has not received flu shot in last 3 years. Past participants will receive the same type of vaccine they received with their prior study vaccine assignment - either the intramuscular (standard flu shot into the arm muscle) or the intradermal (into the skin of the arm) vaccine.  New participants will receive intramuscular (standard flu shot into the arm muscle) vaccine.  All vaccines are licensed by the FDA and are not experimental. These are the same seasonal flu vaccines that will be used for the public during the fall flu season.

The study will compare the B-cell immune responses by analyzing the trafficking receptor expression on vaccine-induced plasmablasts, their immunoglobulin gene-repertoire, as well as functions of PPAb derived from plasmablast subsets based on trafficking receptor phenotypes.

The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program) and Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection)

To be eligible, must have either previously participated in our flu vaccine studies in 2012 and/or 2013 or you are new participant who has not received a flu shot in last 3 years. In addition you should be:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu





Flu
Genetic and Environmental Factors in the Response to Influenza Vaccination; SLVP028 (Twin Study)

 


SUMMARY
The Stanford-LPCH Vaccine Program is seeking healthy twins, 12-49 years old to take part in an influenza vaccine study (commonly known as "the flu").  We hope to understand the cell responses to influenza vaccination in Monozygotic (MZ) and Dizygotic (DZ) twins to determine the roles of genetic and environmental in the response to vaccination. 

The flu vaccine used in this study is licensed by the FDA and is not experimental.  The research will be conducted at Stanford University by Cornelia L. Dekker, MD, Professor of Pediatrics, William Hewitt Robinson, MD, PhD, Associate Professor of Medicine/Immunology & Rheumatology, and Catherine Blish, MD, PhD, Assistant Professor of Medicine.  The trial is sponsored by the National Institutes of Health.
 
To be eligible you should be:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule  **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu




CD4The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection -Influenza-specific DR1501+ or DR0701+ T cells
T-cell Study for identical twin participants_ SLVP031

 The purpose of this NIH-sponsored clinical trial is to provide a better understanding of the adaptive immune response to the licensed flu vaccine in identical twin volunteers who have previously participated in one of our flu vaccine studies in the past. We hope the information learned from this study will help identify and describe important factors of influenza immunity for specific proteins associated with T-cell immune responses.

Volunteers will receive one of two FDA-licensed influenza vaccines, either the inactivated vaccine given as a flu shot, or the live, attenuated vaccine given as a nasal spray. These are the same seasonal flu vaccines that are used for the public during the flu season.

The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), and Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection)

Eligibility: The study is open to specific identical twin volunteers who have previously participated in flu vaccine studies at Stanford-LPCH Vaccine Program. To be eligible, you should be:

You will receive compensation and parking vouchers for your participation.

ELIGIBILITY:

To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:
Please contact us:             
Stanford-LPCH Vaccine Program
(650) 498-7284
Vaccines_Program@stanford.edu






Adult Seasonal Flu Vaccine Study - Longitudinal Study



Flu

Immune Senescence in the Elderly: Comparison of Immune Reponses to Influenza Vaccine in Adults of Different Age Groups



SUMMARY The Stanford-LPCH Vaccine Program is seeking healthy adults to take part in an influenza vaccine study (commonly known as "the flu").  We hope to discover new biological markers that are associated with the age-related immune response to the seasonal flu vaccine. 
The flu vaccine used in this study is licensed by the FDA and is not experimental.  Because we are interested in understanding how the immune response changes over time in the same individual, volunteers will be asked to participate annually through the end of the funding period.

The research will be conducted at Stanford University by Cornelia L. Dekker, M.D., Professor of Pediatrics, and by Mark M. Davis, Ph.D., Professor of Microbiology and Immunology.  The trial is sponsored by the National Institutes of Health, and the Bill and Melinda Gates Foundation.

To be eligible you should be:
Generally Healthy                                                                                            
18-30 or 60-100 years old at time of enrollment
Able to attend 3 clinic visits at Stanford
Able to provide 3 blood samples

If eligible, you will receive:
Current licensed seasonal flu vaccine
$30 per clinic visit attended
Parking vouchers

ELIGIBILITY:
The study is open to volunteers who have been previously enrolled in this study and to new volunteers. To view the eligibility requirements and visit schedule, please click this link: ** Eligibility Criteria and Visit Schedule  **

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu




Immune Responses to Influenza-like Illness (Enrollment Closed)

ILI_virusSummary:  Stanford LPCH Vaccine program is seeking children age 1-3 years old or  adults, age 18 years or older, who are currently experiencing flu-like symptoms to participate in a flu research study. The research will be conducted at Stanford University by Dr. Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Mark M. Davis, Ph.D., Professor of Microbiology and Immunology and Dr. Harry B. Greenberg, M.D., Senior Associate Dean for Research.  The goal is to investigate how the adult immune system responds to natural infection by this season’s influenza viruses.

Study Participation, to qualify you must have:

If eligible, you will receive:

ELIGIBILITY:
To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link: ** Eligibility Criteria and Visit Schedule **

For further information or to volunteer:

Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu

 



 

Stanford Medicine Resources:

Footer Links: